[chirp_users] Connecting to my FT2DR

Running Linux Mint 18.2

Loaded newest release version of Chirp-daily (CHIRP daily-20171013)

When I try to download from radio, this error message is displayed before I can press send on the radio

X An error has occurred Could not configure port: (5, 'input/output error')

Attached png is screengrab

I did some further digging and tried the first 10 "ttyS*" with the same results.

lsusb command provides bus and device numbers but not which ttyS* is in use.

Any Help?