One prolific chip programming cable "gotcha" I haven't heard anyone
mention is using the right USB port. Once you get it working by
manually installing the old version of the prolific driver you have to
plug your programming cable into that exact same USB port on your
computer every time. I ran into this one after trying to reprogram a
radio after a few months of use. After an hour or so of head
scratching I switched ports and boom it worked perfectly again.