I also believe that the current FTDI chipset will remember its com port number even if you plug it into a different USB port which is nice and you aren't plugging the cable in only to tell you it is Com54. :) Hence the reason you might want to clean up your old ports with what I sent earlier.It is hard to solve if you only get the USB to radio programming cable and you have no choice but to back rev their driver.If you go for the RS232 to radio programming cable, then you do have the option of using a USB certified RS232 port. Going back to the RS232 (DB9 connector) is my failsafe that always works.Mike va3mw