I have used CHIRP numerous times for the UV 5R.  I agree with the Dean most issues I ran into were from the connector not seating correctly. Also updating or reinstalling the driver solved the issue 

On Wed, Mar 17, 2021 at 12:24 AM Dean Berglund <deanberg2044@gmail.com> wrote:
Steven, Next time please include your message in the body of the message
rather than just the subject. Rather than delete the program which is a
good program, maybe look into the possibility the driver isn't correct
for the cable you are using. You should also look at the cable where it
enters the radio. Sometimes you have to push it in hard to get it seated
completely or, I had to do this, I had to trim the sides of the cable
where it enters the radio because the plastic was hitting and didn't
allow the plug to insert all the way. Check out miklor.com for more info.
Dean KC9REN

On 3/16/2021 11:00 PM, Steven Feddersen wrote:
>
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