Ok, I was able to reproduce this with my pl2303 clone cable. 
I submitted a patch that should slow down the upload a bit which should work for you.
Expect that to reach daily build within a day or two. In the mean time, you can rollback to a previous version that worked for you to upload (probably, pre December.)

On the original issue, I went back to before I was messing with vx-3 driver, and it seems that provisioning a blank/new channel doesnt work properly (at least from what I can tell as far back as I can see.) There seems to be some issues in the way mask/unmasking/deletion of new channels happens. Anyhow, that will take some more time to debug and fix. 
Not completely sure, but It's possible that a workaround to this is to copy/paste existing channel memories over to new/blank ones, then change the edit the new channel.

-Jens

From: bob <n612dw@gmail.com>
To: chirp_users@intrepid.danplanet.com
Sent: Saturday, February 22, 2014 9:03 PM
Subject: [chirp_users] [vx-3] - daily build with vx3 fix will not upload to radio

After downloading the latest daily build that has a fix (posted by Jens 3
days ago) in it to allow empty memories to be modified/imported, now I can't
upload an image just downloaded of the radio.  The fix posted 3 days ago to
address the issue with not allowing empty memories to be modified/edited or
imported now works, but now we have this problem.

Included the downloaded image from the radio (same as the other day).
Trivially easy to replicate.  Download from the radio and without any
changes, simply try to upload that stuff just downloaded. Toast.

Cant upload the file just downloaded from the radio even without any
changes.

The Radio begins receiving, the Chirp program thinks its done and apparently
stops sending, and the Radio stops indicating data is uploading and just
errors out (probably a timeout).  Is Chirp missing the vx3 equivalent of a
checksum or eof?  Seems like it just still thinks more data is coming.  Once
an error occurs, all memory is wiped.

Wish I knew more about how the upload/download images work...

-bob

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