I am trying to program my Kenwood TM281 for the first time. I'm using Windows 10. I previously ran Chirp to program a Wouxon hand held and it worked fine with that cable.

I have a Prolific cable I got from BlueMax49ers. The instructions said it was a genuine Prolific chip and to use the latest drivers. So I checked and it is using the latest drivers (3.8.28.0). When I started Chirp, I plugged in the radio, and selected "Download from Radio". It gave me a dialog with Com3 preselected, and I selected Kenwood and TM281. When I clicked OK in the dialog, I get this message:

An ERROR Has Occurred
could not open port COM4: [Error 5] Access is denied.

I tried Com3, and got the same error.

An ERROR Has Occurred
could not open port COM3: [Error2] The System Cannot find The File specified.

(this may be the original error, I don't know. I changed the com port to Com4 before writing down what the original error was when it originally went to Com3)

I looked into Device Manager, and under Ports (Com and LPT) It says the Prolific USB to Serial Comm Port (Com4)

I looked at the Properties and it says this:

Does this sound familiar?

Steve