The problem is usually an incompatible driver has been installed. Not necessarily because you installed the wrong drive, but because Windows automatically updated it to an incompatible driver. Visit the
miklor.com website home page for the UV-5R and follow the instructions on the USB driver page to determine if you have the correct driver installed, a source for the correct driver and instruction for how to properly install it.
This website also has Error Message FAQs that will help you trouble shoot your computer to radio interface problem.