[chirp_users] fail programming a Jetstream JT270M

I am attempting to program a Jetstream JT270M using a Prolific cable.

The CHIRP Error message pop-up says

An error has occurred could not open com4 (Error 2) The system can not find the file specified.

In the WIN10 Device manager listing for COM4 it says Driver provide is prolific Date is 10-17-2017 Version is 3.8.18.0

Device status is This device cannot start. (Code 10) A device which does not exist was specified.

Can anyone help me out with this?