Make sure to use the right Drivers. you need version 3.2.0.0 prolific driver. you can get them from www.miklor.com.

I run it on windows 10 with 8 gigs of ram with no problems

Welcome to my world Lamar. Same issue with Windows 7. 

On Wednesday, June 6, 2018, 7:11:41 AM PDT, Lamar Brown <dlamarbrown@gmail.com> wrote:

I have downloaded latest version on computer with Windows 10 and can't download radio to computer so I could add some new frequencies.  It comes up saying there was an error and couldn't open the port.

Lamar

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